Membranes with the Same Ion Channel Populations but Different Excitabilities

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Membranes with the Same Ion Channel Populations but Different Excitabilities

Electrical signaling allows communication within and between different tissues and is necessary for the survival of multicellular organisms. The ionic transport that underlies transmembrane currents in cells is mediated by transporters and channels. Fast ionic transport through channels is typically modeled with a conductance-based formulation that describes current in terms of electrical drift...

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Same ion channel populations and different excitabilities: beyond the conductance-based model

Multicellular organisms rely on electrical signaling to communicate messages within and between different tissues. Channel-mediated ionic transport is typically modeled with conductance-based formulations that assume currents are the result of ionic electrical drift, without taking diffusion into consideration [1]. In contrast, formulations of current that assume ionic flux depends on electrica...

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ژورنال

عنوان ژورنال: PLoS ONE

سال: 2012

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0034636